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Search Results for " von willebrand factor "

Targets Recommended: Vasopressin Receptor

5

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T5144	Desmopressin acetate (16679-58-6 free base) Desmopressin acetate,醋酸去氨加压素,DDAVP	Vasopressin Receptor	GPCR/G Protein
	Desmopressin acetate (16679-58-6 free base) (DDAVP) 是抗利尿激素精氨酸加压素的合成类似物。
T78666	Egaptivon pegol ARC 1779	Integrin	Cytoskeletal Signaling
	Egaptivon pegol (ARC1779)为一种核酸适配体，能够阻断von Willebrand Factor (VWF)与血小板GPIb受体的结合，从而展现其抗血栓功能。
T79188	BT100	Integrin	Cytoskeletal Signaling
	BT100 为一核酸适配体，能够抑制血管性血友病因子(von Willebrand factor, VWF)与血小板糖蛋白GPIb之间的结合，旨在预防动脉血栓的形成。
T78283	Caplacizumab ALX-0081,ALX-0681
	Caplacizumab (ALX-0681)为人源化抗血管性血友病因子(vWF)纳米抗体，具有抑制vWF介导的血小板粘附作用，可阻止微血栓进一步形成。该化合物在血栓性血小板减少性紫癜（TTP）研究中应用。
T36221	2-chloro Palmitic Acid
	2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endot...

化合物

Desmopressin acetate (16679-58-6 free base)

Cat.No: T5144

Synonym: Desmopressin acetate,醋酸去氨加压素,DDAVP

Target: Vasopressin Receptor

Egaptivon pegol

Cat.No: T78666

Synonym: ARC 1779

Target: Integrin

Cat.No: T79188

Target: Integrin

Cat.No: T78283

Synonym: ALX-0081,ALX-0681

2-chloro Palmitic Acid

Cat.No: T36221

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01075	Von Willebrand Factor/vWF Protein, Human, Recombinant (His) von Willebrand factor,VWD,F8VWF	Human	CHO Cells
	Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vascular injury. From studies it appears that VWF protein uncoils under these circumstances, decelerating passing platelets. VWF protein is deficient or defective in von Willebrand disease (VWD) and is involved in a large number of other diseases, including thrombosis, thrombotic thr...
TMPH-02974	Von Willebrand Factor/vWF Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Von Willebrand Factor/vWF Protein, Mouse, Recombinant (His & Myc) is expressed in E....
TMPY-01755	VWC2 Protein, Human, Recombinant (His) PSST739,von Willebrand factor C d...	Human	HEK293 Cells
	Brorin, also known as brain-specific chordin-like protein, von Willebrand factor C domain-containing protein 2 and VWC2, is a secreted protein that contains two VWFC domains. VWC2 / Brorin is a BMP antagonist that may play a role in neural development. It promotes cell adhesion. VWC2 / Brorin is a unique member of the chordin family. It inhibited the activity of bone morphogenetic protein 2 (BMP2) and BMP6 in mouse preosteoblastic MC3T3-E1 cells. Mouse Brorin was predominantly expressed in neura...
TMPH-02484	ADAMTS13 Protein, Mouse, Recombinant (His & Myc) ADAM-TS 1,A disintegrin and metalloproteinase with thrombosp...	Mouse	E. coli
	Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. ADAMTS13 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.7 kDa and the accession number is Q769J6.
TMPY-05716	Integrin alpha V beta 3 Protein, Human, Recombinant (His) Integrin α V β 3,Integrin alpha V β3	Human	HEK293 Cells
	Integrin alpha-V & beta-3 (ITGAV/ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor.
TMPH-00216	SVMP Protein, Bothrops jararaca, Recombinant (His & KSI)	Bothrops jararaca	E. coli
	Metalloproteinase that binds to von Willebrand factor (VWF) and induces its interaction with GPIb (GP1BA), resulting in platelet aggregation. SVMP Protein, Bothrops jararaca, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 18.0 kDa and the accession number is P22028.
TMPJ-01177	NOV/CCN3 Protein, Mouse, Recombinant (His) CCN family member 3,Nephroblastoma-overexpressed gene protei...	Mouse	HEK293 Cells
	NOV, also called CCN3, is a secreted protein of CCN family members. CCN family members are highly conserved cysteine rich proteins sharing a common modular structure having 4 conserved domains, insulin-like growth factor-binding protein (IGFBP) domain, von Willebrand type C (VWC) domain, thrombospondin-1 (TSP-1) domain, and C-terminal (CT) domain (absent in CCN5). By specific interactions with these domains, CCN proteins modulate multiple signalling pathways including BMPs, Wnt, TGFs, Notch and ...
TMPY-00950	WISP1/CCN4 Protein, Human, Recombinant (His) WISP1c,WISP1i,CCN4,WNT1 inducible signaling pathway protein ...	Human	HEK293 Cells
	CCN4/Wnt-induced secreted protein 1 (WISP1) is a secreted, cysteine-rich, heparin-binding glycoprotein, belonging to the CCN (CTGF/CYR61/NOV) family of growth factors, and is involved in diverse biological functions such as cell growth, adhesion, migration, angiogenesis, tissue repair, and regulation of extracellular matrix. Members of the CCN family demonstrate high structural homology sharing four conserved cysteine-rich modular domains: an IGFBP (insulin-like growth factor-binding) domain, a ...

重组蛋白

Von Willebrand Factor/vWF Protein, Human, Recombinant (His)

Cat.No: TMPY-01075

Species: Human

Expression System: CHO Cells

Von Willebrand Factor/vWF Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02974

Species: Mouse

Expression System: E. coli

VWC2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01755

Species: Human

Expression System: HEK293 Cells

ADAMTS13 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02484

Species: Mouse

Expression System: E. coli

Integrin alpha V beta 3 Protein, Human, Recombinant (His)

Cat.No: TMPY-05716

Species: Human

Expression System: HEK293 Cells

SVMP Protein, Bothrops jararaca, Recombinant (His & KSI)

Cat.No: TMPH-00216

Species: Bothrops jararaca

Expression System: E. coli

NOV/CCN3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01177

Species: Mouse

Expression System: HEK293 Cells

WISP1/CCN4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00950

Species: Human

Expression System: HEK293 Cells

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